Median-based incremental cost-effectiveness ratios with censored data

Statistical Inference for Costs and Incremental Cost - Effectiveness Ratios with Censored Data

Statistical Inference for Costs and Incremental Cost-Effectiveness Ratios with Censored Data. (May 2012) Shuai Chen, B.S., Peking University Co–Chairs of Advisory Committee: Dr. Hongwei Zhao Dr. Lan Zhou Cost-effectiveness analysis is widely conducted in the economic evaluation of new treatment options. In many clinical and observational studies of costs, data are often censored. Censoring brin...

Acceptance of health technology assessment submissions with incremental cost-effectiveness ratios above the cost-effectiveness threshold

OBJECTIVES In health technology assessment (HTA) agencies where cost-effectiveness plays a role in decision-making, an incremental cost-effectiveness ratio (ICER) threshold is often used to inform reimbursement decisions. The acceptance of submissions with ICERs higher than the threshold was assessed across different agencies and across indications, in order to inform future reimbursement submi...

Using inverse-weighting in cost-effectiveness analysis with censored data.

Due to induced dependent censoring, estimating mean costs and quality-adjusted survival in a cost-effectiveness analysis using standard life-table methods leads to biased results. In this paper we propose methods for estimating the difference in mean costs and the difference in effectiveness, together with their respective variances and covariance in the presence of dependent censoring. We cons...

On Projection of Costs and Incremental Cost-Effectiveness Ratios: A Data Example

Cost and cost-effectiveness analysis has been more and more important to both policy makers and clinicians in assessing health care delivery. The incremental costeffectiveness ratio (ICER) is widely used inpractice to evaluate the relative health benefit of one treatment over another. Due to the short time span ofclinical trials, the cost estimated from observed data are often right censored. T...

Incremental Cost-Effectiveness (ICE) Concepts